Research on Raman Spectroscopy−Based Quantitative Analysis of Fatty Acid Compositions of Lipid Droplets in Live Cells is Published in Analytical Chemistry
On March 2026, the results of research by Professor Hidetoshi Sato, School of Biological and Environmental Sciences on Raman Spectroscopy−Based Quantitative Analysis of Fatty Acid Compositions of Lipid Droplets in Live Cells were published in Analytical Chemistry. Fat consists of many types of fatty acids. Cells in our body consume fatty acids for energy and convert it into a different type of fatty acid. In contrast, each fatty acid acts differently in different cells. For example, fat cells tend to accumulate linoleic acid, while liver cells induce cell death with linoleic acid. To study behaviors of fatty acids in detail, a technique to quantitatively analyze the fatty acid composition in fat within live cells is necessary, but no such technique had been existed. Prof. Sato’s group developed a technique based on Raman spectroscopy, chemometrics and data simulation, successfully creating calibration models of non-existent reagents. This technology ushers in a new era for human body fat analysis, contributing to pre-symptomatic diagnosis and health management through optical non-invasive analysis.
Journal name: Analytical Chemistry
Article title: Raman Spectroscopy−Based Quantitative Analysis of Fatty Acid Compositions of Lipid Droplets in Live Cells
Author(s): Pradjna N. Paramitha, Keita Iwasaki, Bibin B. Andriana, Yurika Otoki, Ibuki Kusumoto, Yukihiro Ozaki, Kiyotaka Nakagawa, and Hidetoshi Sato